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Sens Foundation Information

The SENS Foundation (Strategies for Engineered Negligible Senescence Foundation) is a non-profit organization co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in California, United States. Its activities include SENS-based research programs and public relations work for the acceptance of and interest in scientific rejuvenation research. Before the Foundation was launched in March 2009, the SENS research program was mainly pursued by the Methuselah Foundation, co-founded by Aubrey de Grey and David Gobel.

Contents

Goals

The foundation's stated goal is "to develop, promote and ensure widespread access to rejuvenation biotechnologies which comprehensively address the disabilities and diseases of aging"; It defines "rejuvenation biotechnologies" as "the application of regenerative medicine – defined to include the repair of living cells and extracellular material in situ – to the diseases and disabilities of aging." Its aims to achieve this by accelerating the various research programs that go together to make the SENS project, by sponsoring university research, and prioritizing those aspects of SENS that are not adequately funded by other means.

SENS Research

Main article: Strategies for Engineered Negligible Senescence

From his biogerontology work, de Grey believes there to be seven categories of cellular damage that constitute agedness, or as he puts it, "the set of accumulated side effects from metabolism that eventually kills us,"[1] all of which are reversible.[2] In order to repair each type of aging damage, de Grey has also developed seven intervention strategies.[3]

Seven types of aging damage and SENS solutions:[2]
  1. Cell loss and cell atrophy — Stem cells and tissue engineering ("RepleniSENS")[4]
  2. Nuclear [epi]mutations — WILT, short for "Whole-body Interdiction of Lengthening of Telomeres" ("OncoSENS")[5]
  3. Mitochondrial mutations — Allotopic expression of 13 proteins ("MitoSENS")[6]
  4. Death-resistant cells — Targeted removal ("ApoptoSENS")[7]
  5. Extracellular crosslinks — AGE-breaking molecules and tissue engineering ("GlycoSENS")[8]
  6. Extracellular aggregates — Stimulating of the immune system to clear out the aggregates ("AmyloSENS")[9]
  7. Intracellular aggregates — Equipping the lysosome with enzymes capable of degrading the aggregates ("LysoSENS")[10]

The Foundation is currently funding projects in LysoSENS, MitoSENS, and OncoSENS.[2]

As of March 2009, over $6 million in donations have been pledged for SENS research.[11]

Staff

This article is in a list format that may be better presented using prose. You can help by converting this article to prose, if appropriate. Editing help is available. (July 2010)

The founders of the SENS Foundation:[12]

Board of Directors:[13]

Other key staff members:

Donors and volunteers

On September 16, 2006, Peter Thiel, co-founder and former CEO of the online payments system PayPal, announced that he is pledging $3.5 million to the Methuselah Foundation "to support scientific research into the alleviation and eventual reversal of the debilities caused by aging" (SENS research).[16] Justin Bonomo, professional poker player, has pledged 5% of his tournament winnings for SENS research.[17] Sam Harris, a prominent nonfiction writer and scientific skeptic, is a Methuselah Mouse Prize 300 member.[18]

References

  1. ^ Than, Ker (April 11, 2005). "Hang in There: The 25-Year Wait for Immortality". LiveScience Health SciTech. http://www.livescience.com/humanbiology/050411_aubrey_interview.html. Retrieved 2009-03-14.
  2. ^ a b c "Research Themes". SENS Foundation. http://sens.org/sens-research/research-themes. Retrieved 2010-12-17.
  3. ^ de Grey, Aubrey; & Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. New York, NY: St. Martin's Press. pp. 416. ISBN 0312367066.
  4. ^ "RepleniSENS". SENS Foundation. http://sens.org/sens-research/research-themes/replenisens. Retrieved 2010-12-17.
  5. ^ "OncoSENS". SENS Foundation. http://sens.org/sens-research/research-themes/oncosens. Retrieved 2010-12-17.
  6. ^ "MitoSENS". SENS Foundation. http://sens.org/sens-research/research-themes/mitosens. Retrieved 2010-12-17.
  7. ^ "ApoptoSENS". SENS Foundation. http://sens.org/sens-research/research-themes/apoptosens. Retrieved 2010-12-17.
  8. ^ "GlycoSENS". SENS Foundation. http://sens.org/sens-research/research-themes/glycosens. Retrieved 2010-12-17.
  9. ^ "AmyloSENS". SENS Foundation. http://sens.org/sens-research/research-themes/amylosens. Retrieved 2010-12-17.
  10. ^ "LysoSENS". SENS Foundation. http://sens.org/sens-research/research-themes/lysosens. Retrieved 2010-12-17.
  11. ^ "Donation Details". Methuselah Foundation. http://www.mfoundation.org/index.php?pagename=fundsdetaildisplay. Retrieved 2009-03-14.
  12. ^ http://www.sens.org/sens-foundation/founders
  13. ^ http://www.sens.org/sens-foundation/board
  14. ^ http://www.sens.org/ai/
  15. ^ http://www.sens.org/rc
  16. ^ Davidson, Keay (September 18, 2006). "BAY AREA — Entrepreneur backs research on anti-aging — Scientist says humans could live indefinitely". San Francisco Chronicle. http://sfgate.com/cgi-bin/article.cgi?f=/c/a/2006/09/18/BAGF5L7LQS1.DTL. Retrieved 2009-03-14.
  17. ^ "Please Welcome the Newest Members of The Three Hundred". Methuselah Foundation Blog. Methuselah Foundation. January 18, 2007. http://blog.methuselahfoundation.org/2007/01/please_welcome_the_latest_memb.html. Retrieved 2009-03-14.
  18. ^ "Sam Harris is a 300 member?". Methuselah Foundation forums. Methuselah Foundation. March 11, 2009. http://www.mfoundation.org/forums/showthread.php?t=1240. Retrieved 2009-04-09.
· · Life extension
Issues Anti-oxidants · Calorie restriction · Cryonics · Exercise · Free-radical theory · Gerontology · Glycation · Indefinite lifespan · Index of life extension-related articles · Longevity · Mind uploading · Rejuvenation · Senescence · Stem cell treatments · Strategies for Engineered Negligible Senescence · Suspended animation
People Marios Kyriazis · Aubrey de Grey · Saul Kent · Terry Grossman · Leonard Hayflick · Denham Harman · Ray Kurzweil · Durk Pearson · Sandy Shaw · Roy Walford · Michael D. West
Organizations Alcor Life Extension Foundation · Alliance for Aging Research · American Academy of Anti-Aging Medicine · American Aging Association · American Cryonics Society · Cryonics Institute · Cryonics Society · Immortalist Society · Immortality Institute · KrioRus · Life Extension Foundation · Methuselah Foundation · SENS Foundation
Books Life Extension (1982) · The First Immortal (1998) · The Scientific Conquest of Death (2004) · Fantastic Voyage (2004) · Ending Aging (2007) · TRANSCEND: Nine Steps to Living Well Forever (2009)
Categories Life extension

Categories: Life extension | Gerontology | Organizations established in 2009 | Non-profit organizations based in California

 

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